Sotirios George Stergiopoulos
Person
Sotirios George Stergiopoulos is a physician, medical researcher, and biotechnology executive who co-founded Coiled Therapeutics PLC, where he serves as Executive Chairman and Chief Medical Advisor. He has also held leadership roles in biotechnology and healthcare and has published research in endocrinology and genetics.
What Sotirios George Stergiopoulos has said on podcasts
11 statements
AO-252 reaches brain tissue at roughly blood-equivalent levels.
“Our ability to actually have pretty much on a 1-to-1 level of what the, the in the blood versus what's in the brain”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 11:03
AO-252 has an approximately 80% clinical benefit rate.
“our clinical benefit rate is at about 80%.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 13:08
AO-252 reduced a tumor by 30% in a heavily pretreated patient.
“it still takes 30% of the tumor down.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 13:41
AO-252 can convert immunologically cold tumors into hot tumors.
“We're able to transform that and really make it into a hot tumor.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 17:11
Coiled Therapeutics intends to avoid becoming a commercial entity.
“we're not looking to become a commercial entity ourselves in any way”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 23:51
AO-252 could address a market approaching or exceeding $100 billion.
“you could be reaching anywhere close to $100 billion plus.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 25:03
AO-252 may have applications beyond cancer.
“Could there potentially be other uses? Yes, potentially they can”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 29:23
AO-252 will become a major blockbuster and justify buying Coiled shares.
“this is going to be a huge blockbuster, we believe, and one that will definitely be worth the buying of the share.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 31:37
AO-252 is worth substantially more than its implied £6–8 million value.
“the value is much greater than that.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 32:23
AO-252 has already demonstrated tumor effects below its maximum tolerated dose.
“we've already shown that that's the case, and we showed it with doses that aren't even at the maximum tolerated dose yet.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 32:51
Coiled expects clinical answers on AO-252 within months, not years.
“we'll have our answers fairly quickly.”
Open the episode · S11 Ep68: Sunday Roast featuring Coiled Therapeutics PLC and Halo Resources #COIL #HALO #EPP #DELTA #KEN #AEGListen at 35:07
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
2 episodes featuring Sotirios George Stergiopoulos
The Sunday Roast
Guardian Metal weighs tungsten’s strategic upside
The episode connects Pilot Mountain and Tempiute to US tungsten supply, project financing and a broader revival of uranium investment in Italy.
Jul 5, 2026 · 1h 36m
The Sunday Roast
Biotech promise meets copper development risk
The episode contrasts Coiled Therapeutics’ clinical ambitions with Halo Minerals’ path from permitted project to copper production and expansion.
May 10, 2026 · 1h 9m