Play-related endogenous opioids

What experts have said about Play-related endogenous opioids

1 statement · 1 positive

1. Andrew David HubermanPositiveJan 29, 2026· Huberman Lab Essentials

   Play-related endogenous opioids improve prefrontal-cortex flexibility.

   “when the periaqueductal gray releases these endogenous opioids during play, the prefrontal cortex doesn't get stupid. It actually gets smarter.”

   Listen at 2:10

   Open the episode · Essentials: Using Play to Rewire & Improve Your Brain

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