Jan 29, 2026 · 35 min
Voluntary play biologically rewires the adult brain to enhance cognitive function
Essentials: Using Play to Rewire & Improve Your Brain
Understanding the biological mechanisms of play allows adults to intentionally leverage play-based behaviors to improve brain plasticity and executive function.
- 1Voluntary play triggers neuroplasticity by activating the periaqueductal gray and releasing endogenous opioids like enkephalin.
- 2Engaging in play-based behaviors directly stimulates the prefrontal cortex to improve essential executive functions.
- 3Adults can leverage play as a practical protocol to enhance cognitive flexibility and daily self-control.
The brief
Play is not just a recreational activity for children; it is a powerful biological driver that actively reshapes the adult brain. Stanford neurobiologist Andrew Huberman explains how voluntary play triggers neuroplasticity and alters neural circuitry.
Engaging in play activates the periaqueductal gray, a brain region critical for motivated behavior, and stimulates the release of endogenous opioids like enkephalin. This chemical release helps regulate pain and emotional responses during novel activities.
The neurological impact of play extends directly to the prefrontal cortex. By stimulating this region, play-based behaviors help enhance executive function, improving cognitive flexibility, working memory, and daily self-control.
Featuring
Andrew David Huberman
Periaqueductal gray
enkephalinListen to the full episode and explore every guest, topic, and moment on PodLume.