APOE4 gene
Topic
APOE4 (Apolipoprotein E4) is a major genetic variant of the APOE gene, which provides instructions for making a protein that helps carry cholesterol and other fats in the bloodstream. It is the strongest genetic risk factor for late-onset Alzheimer's disease, with individuals carrying one or two copies of the allele having a significantly increased likelihood of developing the condition. Beyond Alzheimer's, the APOE4 allele is also associated with an increased risk of cardiovascular disease and cognitive decline.
What experts have said about APOE4 gene
7 statements · 5 negative · 2 neutral
APOE4 is among the strongest genetic risk factors for Alzheimer’s disease.
“The APOE4 gene is one of the strongest risk factors of getting Alzheimer's disease.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 1:20
Carrying APOE4 does not make Alzheimer’s disease inevitable.
“But it is not a foregone conclusion that you're going to get it.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 1:27
One APOE4 copy raises Alzheimer’s risk two to threefold.
“when you have a copy of the APOE4 gene, it raises your risk by two to three times.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 2:06
Two APOE4 copies raise Alzheimer’s risk tenfold.
“If you have two copies of the gene, it raises your risk by 10 times.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 2:13
One APOE4 copy raises Alzheimer’s risk about sixfold in females.
“one copy of the gene of APOE4 gene for a female raises your risk by about six fold”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 2:30
APOE4 appears to increase CTE severity risk after significant repetitive head impacts.
“Apoa 4 appears to increase the risk of severity of chronic traumatic encephalopathy in people with significant repetitive head impacts.”
Open the episode · JRE MMA Show #179 with Josh Thompson & "Big" John McCarthyListen at 1:40:58
APOE4 has no apparent effect without repeated head impacts.
“and you're not taking headshots, you're okay. It doesn't do anything.”
Open the episode · JRE MMA Show #179 with Josh Thompson & "Big" John McCarthyListen at 1:41:12
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
