Phenotypic Reversion

Topic

Phenotypic reversion is a biological process in which a mutated, diseased, or malignant cell transitions back to a normal, benign, or wild-type physical state. This phenomenon is widely studied in oncology (often termed tumor reversion), where cancer cells are induced to adopt non-malignant phenotypes through epigenetic reprogramming, microenvironmental cues, or physical forces. It is also observed in genetics and microbiology, such as when drug-resistant bacteria revert to drug-sensitive states in the absence of selective pressure.