Melanocortin 1 receptor (MC1R)

Topic

The melanocortin 1 receptor (MC1R), commonly referred to as the 'redhead gene', is a key protein-coding gene involved in regulating skin and hair color in mammals. Recessive mutations in this gene lead to a buildup of pheomelanin, resulting in red hair, fair skin, and freckles. Located on chromosome 16, MC1R is also associated with variations in pain sensitivity and increased susceptibility to UV-induced skin damage.