GABA

Topic

Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. It plays a principal role in reducing neuronal excitability throughout the nervous system and is synthesized from the excitatory neurotransmitter glutamate. Dysfunction in GABA signaling is implicated in various neurological and psychiatric conditions, making it a key target for many pharmacological treatments.